2019-07-30  facebooktwitterrss

UK Test to help USA Farmers Improve Disease Diagnosis

Colorado’s Animal Health Laboratory is to trial the new Actiphage® diagnostic to improve early-stage detection of bovine TB in cattle.

The Animal Health Laboratory within the Colorado Department of Agriculture is assisting in a trial of Actiphage®, a new rapid blood test for bovine Tuberculosis (bTB) developed by UK start-up PBD Biotech that detects early-stage infection in cattle and other animals.


bTB is a contagious and infectious disease caused by Mycobacterium bovis. It primarily affects cattle, but in the USA is known to infect bison, deer, elk and other warm-blooded species. In very rare cases, the disease can also be transmitted to humans through direct contact with infected animals or consumption of raw milk. 

The Colorado Animal Health Lab, an ISO 17025 accredited laboratory, aims to determine the accuracy of the new Actiphage test, particularly in detecting the disease at an early stage, which will assist in the control of infection.

A large number of cattle enter the USA from Mexico – some 1.5 million head per year – and traces of bTB have been detected in this border region over the last 18 months. The pilot study will initially use Actiphage to test blood samples from cattle that have been highlighted as having a high risk of infection.

This trial will be an exploratory project under the Lab Manager, Ms. Tiffany Brigner, with a permit granted by the Center for Veterinary Biologics (CVB), an agency of the USDA. Ms. Brigner explains:
“The control of bTB is very important. Having an assay that can detect bTB quickly and accurately would aid in mitigating the spread of this contagious disease.”

Robert Lyons is Director of North American operations for PBD Biotech, the Suffolk-based company that has developed Actiphage. He explains that the Colorado trial will provide important independent validation of the test, building on the test’s US patent which came into effect earlier this month.

Robert said:
“Actiphage can be used to detect bTB and Johne’s disease in blood or milk samples and has been effectively used in bTB eradication strategies leading to its approval for exceptional private use in cattle in the UK under the Government’s Animal and Plant Health Agency protocol. A trial on this scale will help us to further improve the diagnostic and provide insights into the aetiology of the disease within large herds.”

It comes as the test’s unique, rapid biotechnology is awarded a US patent, to match the key patent awarded by the European Patent Office in 2018.

Actiphage offers vets, farmers, zoology and exotic species experts, food manufacturers and others a rapid tool for early detection of live bacteria, facilitating improved food safety as well as containment and control of the disease.

BPD Biotech

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